Injection Lipolysis

Mesotherapy is a technique by which micro-injections of medication and/or vitamins are injected into the middle layer of skin (mesoderm). Tissues found in the mesoderm include fibrous connective tissue, cartilage, bone, muscle, and fat. Mesotherapy is commonly used for body sculpting, cellulite reduction, and skin rejuvenation.

Lipolysis (to breakdown fat) with mesotherapy
is an effective procedure at improving localized areas of unwanted fat. A mixture of FDA approved medications, vitamins, and minerals are injected into the mesoderm to dissolve the small areas of unwanted fat. Lipolysis is best used for small areas of unwanted fat, whereas liposuction is the treatment of choice for larger areas of fat. The theory is that mesotherapy injections will break down fat and improve circulation of blood and lymphatic fluid, promoting excretion of metabolized fat in the patient’s urine. A series of injections spaced approximately 2 weeks apart are necessary to achieve the desired result. A healthy diet and regular exercise are recommended to maximize fat reduction.


The most common mixture to “burn off” pockets of excess fat or cellulite is:

  • Phosphatidylcholine (This is what we use in our office).

Phosphatidylcholine (PPC) is a liquid form of soy lecithin, an antioxidant which occurs naturally in the body and is FDA approved as a nutritional supplement. It was first used in the 1950s to reduce cholesterol and triglycerides in the blood. PPC acts to penetrate and break up fat cells so they can be eliminated by the body (primarily the kidneys).

Although the individual chemicals are all FDA-approved, the use of the actual mixture is considered “off label”. Off label use of medications is a legal way of utilizing FDA-approved medications for conditions other than those for which it has been approved. There is an interest by the company Aventis to ask for FDA approval of such a mixture under the name of Lipostabil. This will take years.

What are the special advantages of injection Lipolysis?

It achieves a permanent reduction of fat deposits especially those resistant to diet or exercise. The treatment is gentle, virtually, pain free, low in risk, it does not take long. There is no pre or post treatment and no downtime.

How many treatments are necessary?

As a rule 2-4 treatments at intervals of 8 weeks.

Possible Risks & Complications:

  • Mild bruising, redness, warmth, swelling, or itching. A
  • A hardness or lumpiness of the tissue at the injection site(s) that disappears on its own after 2-6 weeks.
  • Hives, nausea, diarrhea, weakness and arrhythmias are rarely seen

Care of the Treated Area:

  • Redness, swelling and tenderness for 24-48 hours followed by gradual decrease in these symptoms, followed by some “hardness” of the injected fat…is normal. This hardness can be softened with warm compresses and will resolve within 2 to 4 weeks
  • It is advised that you avoid vigorous exercise and any anti-inflammatory medications within 48 hours of treatment as they may diminish the results
  • Over the counter Tylenol may be used to relieve any discomfort
  • Compression with a scarf or bandage can help reduce the swelling sensation
  • Diet and exercise along with mesotherapy will maximize fat removal
  • Drink plenty of water to help eliminate the breakdown products from your body
  • Only ice the area if it is absolutely necessary to minimize swelling and discomfort. Ice functions as an anti-inflammatory and can decrease the effectiveness of the injections.
  • Avoid saune visits, massages, and spots/exercise for about 3 days.

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